Consequently, the KYN pathway manifests as a potential target of therapeutic intervention for the antidepressant effects of ketamine. (1) Stress prompts a hyperactivation of noradrenergic neurons, leading to the diminished activation of α2-receptors, ultimately culminating in lowered levels of NE release. Furthermore, DβH represents a rate-limiting step in NE biosynthesis; (2) Chronic restraint stress decreases …
- April 23, 2024
- Sober living
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